异丙酚和芬太尼在胃镜检查中的应用研究

Sedation for gastroscopy with propofoi and sublimaze.

目的探讨联合应用异丙酚和芬太尼在胃镜检查中的镇静效果和安全性。方法1862例胃镜检查病人给予异丙酚和芬太尼镇静为镇静组，1192例给予常规操作（不给任何镇静药）为对照组，比较两组胃镜检查中病人反应和感受，观察其清醒时间及检查前、中、后血压、心率和指脉氧饱和度（SpO2）的变化。结果镇静组99．5％无不适，对照组为5．2％（P〈0．01）。镇静组病人呛咳、体动、恶心呕吐和咽喉不适的发生率分别为0．6％、1．0％、0．8％、0．0％，明显分别低于对照组的63．7％、68．8％、86．6％、34．8％（P〈0．01）。镇静组清醒时间为2．9±1．6min，检查中有血压下降，但检查后迅速恢复至检查前水平。结论胃镜检查时联合应用异丙酚和芬太尼静脉镇静是一种安全、有效的方法。

AIM To study the efficacy and safety of sedation for gastroscopy with a combined use of propofol and sublimaze. METHODS Gastroscopy was performed on 1915 patients under sedation by intravenous propofol and sublimaze, and on 1192 patient without any sedatives as controls. RESULTS Significantly more patients in the sedation group than in the control group went through the procedure without complain about any discomfort or pain （99.5% vs 5.2%, P 〈0.01）. The incidences of cough, restlessness, nausea and vomiting, and guttural discomfort in the sedation group（0.6 %, 1.0 %, 0.8 % and 0 % ）were lower than those in the control group（63.7% ,68.8% ,86.6% ,34.8%, P 〈0.01）. CONCLUSION Gastroscopy can be performed effectively and safely with intravenous application of propefel and sublimaze.