牛磺酸对低出生体质量仔鼠胰岛β细胞超微结构的影响

Influence of Taurine Supplementation on Ultrastructure of Islet β Cells in Neonatal Rats with Low Birth Weight

目的研究生后早期补充牛磺酸对低出生体质量(LBW)仔鼠体质量和胰岛β细胞超微结构的影响。方法给予孕期母鼠10%低蛋白饲料(R组)制造LBW仔鼠模型,并在哺乳期持续同饲料喂养21 d;对照组(C组)母鼠给予20%正常蛋白饲料喂养。在哺乳期给予部分母鼠富含2.5%牛磺酸饮用水营养干预(RT组);其他母鼠自由饮水。于生后d1、21取出胰腺备做电镜标本。结果生后21 d时,RT组仔鼠体质量显著高于R组(P=0.003)。但仍明显低于C组(P=0.01);RT组β细胞超微结构较R组也有明显改善。结论生后早期补充牛磺酸不仅可促使LBW仔鼠的完成部分生长追赶,且能改善其β细胞超微结构。

Objective To observe the influence of taurine supplementation during early postnatal life on body weight and ultrastructure of islet β cells in neonatal rats with low birth weight（LBW）. Methods LBW neonatal rats were made by feeding 20% （C group） or 10% （R group） protein diet to fetal rats during gestation and lactation. Half of femal rats in group R were given a supplementation with 2. 5 % taurine drinking water（RT group） only during lactation,while other femal rats freely drunk. At postnatal day 1 and 21, the neonatal rats were weighted and their pancreas were removed. The ultrastructural changes of β cells were observed by electron microscopy. Results At postnatal 21 days, the body weight of offsprings in group RT was significantly highter than that in group R（ P 0. 003） ;and the ultrastructure of β cells in group RT got more improvement than that in group R. Conclusion Taurine supplementation can improve the growth catch - up and the ultrastructure of islet β cells of neonateal rats with LBW.