缺氧缺血性脑病新生儿血清补体3、4水平变化的意义

Changes of Serum Complement 3 and Complement 4 in Neonates with Hypoxic-Ischemic Encephalopathy and Its Clinical Significance

目的检测缺氧缺血性脑病（HIE）新生儿血清C3、C4的变化，了解HIE对非特异免疫功能的影响。方法HIE新生儿67例，根据生后的年龄和病情轻重分为1～3d组32例，其中轻度HIE14例，中重度HIE18例。4～6d组35例，其中轻度HIE16例，中重度HIE19例。对照组30例为同期在我院产科出生的正常新生儿。采用散射比浊法检测血清C3、C4，结果进行统计学分析。结果1～3d组血清C3、C4在轻、中重度HIE组与对照组比较均差异显著（P〈0．05，0．01）。4-6d组血清C3、C4在轻、中重度HIE组与对照组比较差异显著（P均〈0．01）。1～3d组和4～6d组血清C3、C4轻度与中重度组比较均无显著差异（P均〉0.05）．结论HIE可使患儿补体水平降低．合成补体的功能降低．但与HIE的程度无关。

Objective To detect the changes of serum complement 3（C3 ） and C4 in neonates with hypoxic - ischemic encephalopathy （HIE） and its effects on non specific immunological function. Methods Sixty- seven neonates with HIE and 30 normal full - term infants were recruited in the study. According to characteristic of immunological function and severity of HIE, the neonates were divided into 1 - 3 day group（ n = 32）and 4 - 6 day group（ n = 35 ）. In each group, it was divided into mild group and moderate - severe group. The complement in serum was detected by radial irnmunodiffusion assay with Behring Nephelometer 100 Analyzer. Results In 1 - 3 day group, levels of C3,C4 in serum were lower than those in control group（P 〈0.05,0.01 ）. In 4 - 6 day group, levels of C3,C4 in serum of HIE group were lower than those in control group （ all P 〈 0.01 ）. Conclusions The levels of C3, C4 in serum of HIE decrease. It will damage the immunological function, and severity of HIE does not contribute to change of comolements.