期刊文献+

近亲婚配现状及后代遗传效应初探 被引量:1

The actuality of consanguineous marriage and the offspring genetic effect
下载PDF
导出
摘要 目的:探讨近亲婚配现状及遗传效应,避免近亲婚配。方法:对近亲婚配引起反复流产、死胎或生育智力低下儿者,采用细胞遗传学技术,进行染色体检查,并对其进行核型分析。结果:检查夫妻之一核型异常的占5%,其后代核型异常占5%;夫妻双方核型正常,但反复流产、死胎或生后死亡的占90%。结论:不能排除近亲婚配是造成反复流产及后代异常的重要原因之一。 Objective: To analyze the actuality of consanguineous marriage and the offspring genetic effect. Methods: By the technique of cytogenetics , to analyze the chromosome of couples those who had the history of repeatedly abortion or childbearing history of dead foetus or mental retardation because of consanguineous mating. Results: The percentage of abnormal karyotype in one of a couple and in offspring were both 5%, and the percentage of couples both of whom had normal karyotype, but had the history of repeatedly abortion or dead foetus or postnatal death was 90%. Conclusion: It can not be eliminated that consanguineous marriage is an important reason that causing repeatedly abortion and abnormal offspring.
出处 《中国妇幼保健》 CAS 北大核心 2006年第14期1944-1945,共2页 Maternal and Child Health Care of China
关键词 近亲婚配 不良妊娠 遗传效应 Consanguineous marriage Ⅲ - pregnancy Genetic effect
  • 相关文献

同被引文献12

  • 1周荣富,王鸿利.遗传性蛋白C缺陷症的研究进展[J].国外医学(输血及血液学分册),2005,28(3):227-230. 被引量:9
  • 2包承鑫.遗传性易栓症的诊断[J].诊断学理论与实践,2006,5(5):452-454. 被引量:9
  • 3蔡晓红,周荣富,谢爽,王文斌,戴菁,丁秋兰,方怡,谢飞,王学锋,王鸿利.两个遗传性蛋白C缺陷症家系临床表型和基因型变化的研究[J].中华血液学杂志,2007,28(3):147-151. 被引量:11
  • 4周荣富,蔡晓红,谢爽,王文斌,戴菁,丁秋兰,方怡,谢飞,王学锋,王鸿利.蛋白C基因C64W和F139V突变致蛋白C缺陷的分子机制研究[J].中华血液学杂志,2007,28(3):156-159. 被引量:8
  • 5Griffin JH, Evatt B, Zimmerman TS, et al. Deficiency ofprotein C in congenital thrombotic disease. J Clin Invest, 1981, 68: 1370-1373.
  • 6Ozlu F, Kyotani M, Taskin E, et al. A neonate with homozygous protein C deficiency with a homozygous Arg178Trp mutation. J Pediatr Hematol Oncol, 2008, 30:608-611.
  • 7. Sakata T, Kario K, Katayama Y, et al. Studies on congenital pro- tein C deficiency in Japanese: prevalence, genetic analysis, and relevance to the onset of arterial occlusive diseases. Semin Thromb Hemost, 2000, 26:11-16.
  • 8Lind B, Gedde-Dahl T, Tjonnoord G, et al. Protein C deficiency caused by homozygosity for a novel PROC D180G mutationin vitro expression and structural analysis of the mutation. J Thromb Haemost, 2002, 88:632-638.
  • 9Kovacheva K, Simeonova M, Ivanov P. Inherited thrombophilia and pregnancy with fetal loss. Akush Ginekol (Sofiia), 2007, 46: 8-14.
  • 10Hamamy H. Consanguineous marriages: Consanguineous marriages: preconception consultation in primary health care settings. J Community Genet, 2012, 3:185-192.

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部