介入热灌注化疗栓塞治疗肝脏恶性肿瘤疗效分析

An analysis on the efficacy of transcatheter arterial thermo-chemo-embolization for malignant hepatic tumor

目的探讨介入热灌注化疗栓塞术治疗肝脏恶性肿瘤的疗效。方法对31例肝脏肿瘤患者先经导管缓慢推注小剂量5-Fu,再用中等剂量丝裂霉素与顺铂或卡铂联合经动脉灌注行热化疗(使进入体内温度达到43～48℃),并用阿霉素或表阿霉素与超液态碘油按5∶1的比例混合,栓塞肿瘤供血血管。结果介入热化疗栓塞术后,患者临床症状迅速缓解,碘油均匀弥散并延长充填时间。31例中完全缓解3例,部分缓解11例,轻度缓解8例,无效9例,总缓解率为71%。结论介入热化疗栓塞术是治疗肝脏恶性肿瘤的一种重要方法之一。

Objective To investigate the efficacy of treating malignant hepatic tumor through thermo chemoembolization. Methods All together 31 patients with hepatic malignant tumor were enrolled. The treatment began with the first slow injection of small dose of 5-Fu followed by intraarterial perfusion of thermo-chemotherapy （the temperature of medicine into boby was 43 - 48℃）with middle doses of mitomycin （MMC）,concomitant explatin （CDDP）or canboplatin （CBP）. Finally the adjunct mixture of ultraliquid lipiodol with adriamycin （ADM）or epircibicin （EADM）（the ratio of volume was one to five）,was used to embolize the tumor vessel. Results After transcatheter arterial thermo chemoembolization,the patients＂ clinical symptom relieved rapidly. The homogeneous perfusion of lipiodol can explain the prolongation of embolization period. Among 31 patients, 3 obtained complete relief, 11 with partial relief, 8 of mild relief and 9 with no response. The total rate of relief reached 71%. Conclusions Transcatheter arterial thermo chemoembolization should be an important method in treating malignant hepatic tumor. （J Intervent Radiol, 2006, 15： 405-406）