TACE并射频容性加热治疗转移性肝癌:临床疗效评估

Evaluation of transcatheter arterial chemoembolization combined with radiofrequency capacitive heating on clinical therapeutic effect of metastatic hepatic carcinoma

目的评价TACE并射频容性加热对转移性肝癌的疗效和不良作用。方法转移性肝癌患者39例,分为TACE合并射频容性加热组(治疗组,19例)和常规灌注化疗栓塞(TACE)组(对照组,20例)。两组病例治疗前Karnofsky评分均≥60分。结果肿瘤生长率治疗组为-(0.38±0.22),对照组为-(0.13±0.25),差异有显著性(P<0.05)。近期有效率治疗组为57.9%;对照组为40.0%。治疗后治疗组在热疗的局部1例(5.3%)出现皮下脂肪结节,1例(5.3%)诉有肋骨痛。毒副反应两组差异无显著性(P>0.05)。结论TACE并射频容性加热治疗转移性肝癌能提高临床疗效,不增加毒副反应。

Objective To evaluate clinical therapeutic efficacy and adverse effecacy of transcatheter arterial chemoembolization （TACE）combined with radiofrequency capacitive heating （RCH） for metastatic hepatic carcinoma （MHC）. Methods Thirty-nine cases of MHC were enrolled in this study and divided into two groups： study group （n = 19）and control group （n = 20）. Before therapy, the Karnofsky＇s score of the patients was all beyond 60. Results The carcinoma growth rate of the study group was -（0.38 ± 0.22）, while that of the control group was -（0.13 ± 0.25）, showing significant statistical difference（P 〈 0.05）. The response rates in the study and control group were 57.9% vs 40%. After treatment, local fat necrosis occurred in 1 case （5.3%）, and costal pain in another case（5.3%）of control group. The difference of adverse effects in the study and control group showed no statistical significance （P 〉 0.05）. Conclusion The therapeutic effect of MHC can be further improved by the treatment of TACE combined with radiofrequency capacitive heating without increase of adverse side effects. （J Intervent Radiol, 2006, 15： 407-409）