富血小板血浆对表面多孔性种植体周骨再生的作用

Bone Regeneration Around Sintered Porous-Surfaced Implant with PRP: an Animal Experiment

目的:研究钛合金颗粒熔附表面多孔性种植体在植入时应用富血小板血浆(PlateletRichPlasma,PRP),对种植体周围骨再生的影响。方法:钛合金颗粒熔附表面多孔性种植体30枚分别植入5条狗的双侧下颌骨,左侧种植体在植入时局部应用PRP,右侧为对照组。术后3天、1、3、6及12周分别将动物处死,进行组织学和组织形态学分析。结果:术后3天和1周时,两组的组织学表现及骨-种植体接触率(Bone-implantcontact,BIC)均相似。术后3周时,实验组可观察到骨单位已开始形成,两组的骨-种植体接触率具有显著性差异(PRP组为68.11±17.63%,对照组为44.26±31.79%)。术后6周及12周时两组无明显区别。结论:表面多孔性种植体局部应用PRP可更有利于种植体周围早期骨再生,但PRP加快种植体周围骨再生的机制还有待于进一步的研究。

Object： The aim was to study the effect of adding PP, P to sintered porous-surfaced implants on early bone regeneration.Methods： Sintered porous-surfaced implants （n=30） were placed in both sides of the mandible of 5 mongrel dogs. On the left side the implants were socked in autogenous PRP before installation, named PP, P group. On the opposite side, the implants were placed without PP, P, named control group. At 3 days, 1, 3, 6, and 12 weeks after implantation, the animals were sacrificed and histologic and histomorphometric results were collected respectively.Result：The histologic and histomorphometric analysis was similar between both groups at 3 days and 1 week. At 3 weeks postoperation, the formation of osteons were noted in PP, P group, and there was significant difference about bone to implant contact （BIC） between the specimens of 3 weeks of PP, P group （68.11±17.63%） and control group （44.26±31.79%）. But there was not significant difference about BIC in the specimens of 6 weeks and 12weeks between both groups.Conclusions：The application of PRP could not increase the amount of the bone regeneration around implants, but it was benefit to early （at the 3rd week postoperation） bone regeneration and remodeling.