羟乙桂胺在肌肉挛缩患者及健康志愿者体内的药物动力学

PHARMACOKINETIC STUDIES OF IDROCILAMIDE IN NORMAL VOLUNTEERS AND PATIENTS WITH SPINAL SPASTICITY

９名肌肉挛缩患者和６名健康志愿者口服羟乙桂胺片１５ｍｇ／ｋｇ，用ＨＰＬＣ测定血药浓度并计算动力学参数。９名肌肉挛缩患者口服后的达峰时间Ｔｍａｘ（约１ｈ），峰浓度Ｃｍａｘ（５．５±０．８μｇ／ｍｌ）；ｋａ（１．１９±０．１４ｈ－１），ｔ１／２α（１．０８±０．３１ｈ），ｔ１／２β（３．３７±１．０５ｈ），与健康志愿者无显著差异（ｐ＞０．０５）。

The pharmacokinetics of idrocilamide(1) was studied in 6 normal volunteers and 9 patients with spinal spasticity.The plasma levels of 1 were assayed with HPLC.The main parameters were as follows.Tmax was 1h,Cmax 5.5±0.8kg/ml,k.1.19±0.14h-1;t1/2a.1.08±0.37h,t1/2a 3.37±1.05h,respectively.The pharmacokinetic parameters of 1in normal volunteers and in patients have no significant difference(p>0.05).