PET-CT显像在结肠直肠癌术后复查的临床应用

Clinical practice of PET-CT in diagnosis of postoperative metastasis of colorectal cancer

目的:评价18F-脱氧葡萄糖(FDG)PET-CT显像与CT扫描在诊断结肠直肠癌术后转移与否的准确性。方法:20例临床可疑(血清癌胚抗原(CEA)升高或CT显像阳性或可疑)结肠直肠癌术后转移的患者行全身18F-FDG PET-CT显像,PET-CT显像结果与CT扫描结果对比分析。结果:20例患者共有病灶27个,病理组织学结果及临床随访结果证实,20个恶性病灶,7个良性病灶。PET-CT显像的阳性预测值为94.7%,阴性预测值为75%,CT扫描结果的阳性预测值为81.3%,阴性预测值为36.3%,两者有显著性差异。结论:全身18F-FDG PET-CT显像在诊断结肠直肠癌术后转移与否的准确性高于比CT扫描结果。

Objective：To assess the clinical accuracy of whole-body ^18F-FDG PET-CT in the diagnosis of postoperative metastasis colorectal carcinoma in comparison to conventiona/computed tomography （CT）. Methods： Twenty patients with suspected recurrent colorectal carcinoma based on either progressive serial careinoemrbyonic antigen （CEA） serum elevation or positive/eqnivocal CT findings underwent whole-body FDG-PET. PET results were compared with those of CT and correlated to the final histopathological and clinical findings. Results： A final diagnosis was obtained at 27 sites in 20 patients by histology and clinical follow up of at least 6 months. Of the 27 sites, 20 were determined to be malignant and 7 benign. FDG-PET showed a positive and negative predictive value in the range of 94.7% and 75% respectively. By comparison, CT showed a positive and negative predictive value in the range of 81.3% and 36.3% respectively. Conclusion：The results of this study confirm that whole-body FDG-PET-CT is mere accurate than conventional CT in the staging of patients with suspected recurrent colorectal carcinoma.