Inhibitory effect of Fuzheng Yiliuyin in combination with chemotherapeutics on human gastric carcinoma cell strain

AIM： To study the inhibitory effects of Fuzheng Yiliuyin （Decoction for Suppressing Tumors by Strengthening the Body Resistance） in combination with chemotherapeutics on human gastric carcinoma cell strain. METHODS： Fuzheng Yiliuyin （ZY） combined with various kinds of chemotherapeutics was put into two kinds of cultivated human gastric carcinoma cell strains, then its inhibitory effects on human gastric carcinoma cell strains were determind by the MTT method. Flow cytorneter was used to assay the apoptosis rate, and the ultrastructure of gastric carcinoma cells was observed under transmission electron microscope. RESULTS： Obvious apoptosis was seen in gastric carcinoma cells after treatment with ZY for 72 h. ZY and chemical drugs had synergistic inhibition effects on the cultivated gastric carcinoma cells, but the effects were different on various cell strains. The inhibitory effects of ZY could be strengthened by cytotoxic action and apoptosis. ZY combined with tluorouracil, etoposide and cisplatin （EFP） chemotherapeutics had better inhibitory effects on SGC-7901, while ZY combined with EFP or with DDP chemotherapeutics had better inhibitory effects than other drugs on MGC-803. CONCLUSION： ZY induces apoptosis and inhibits the growth of gastric carcinoma cells. ZY has the synergistic function of chemotherapeutics.

瞄准：在人的胃的癌房间紧张上与化学疗法在联合学习 fuzheng yiliuyin (为由加强身体抵抗压制肿瘤的煎) 的禁止的效果。方法：与化学疗法的各种各样的类型相结合的 Fuzheng yiliuyin (ZY ) 被放进二种有点胃的癌房间紧张，然后，它人的胃的癌房间紧张上的禁止的效果被 MTT 方法决定。流动血细胞计数器习惯于 apoptosis 评估的试金，并且胃的癌房间的超微结构在传播电子显微镜下面被观察。结果：明显的 apoptosis 为 72 h 与 ZY 在胃的癌房间术后疗法被看见。ZY 和化学的药在栽培的胃的癌房间上有协同的抑制效果，但是效果在各种各样的房间紧张上是不同的。ZY 的禁止的效果能被细胞毒素的行动和 apoptosis 加强。ZY 把化学疗法与氟尿嘧啶， etoposide 和 cisplatin (EFP ) 相结合最好 SGC-7901 上的禁止的效果，当 ZY 与 EFP 或与 DDP 化学疗法结合了时最好禁止的效果比 MGC-803 上的另外的药。结论：ZY 导致 apoptosis 并且禁止胃的癌细胞的生长。ZY 有化学疗法的协同的功能。