早产儿动脉导管未闭发病率及消炎痛治疗10年总结

Patent arterial duct in premature infants: the morbidity and effect treated with indomethacin for 10 years

目的探讨早产儿动脉导管未闭的发病率及消炎痛的治疗效果。方法根据早产儿及患动脉导管未闭例数计算早产儿动脉导管未闭的发病率。观察早产儿动脉导管未闭发病率与早产儿体重及胎龄的关系，探讨消炎痛对早产儿动脉导管未闭患儿的治疗效果。结果早产儿动脉导管未闭的发病率为５．０６％（６０／１１８５），出生体重≤１５００克者，其发病率为６．５４％（１０／１５５），～２０００克者为５．２５％（２７／５１４），～２５００克者为４．８８％（１９／３８９），≥２５００克者为３．１５％（４／１２７），各组发病率有显著性差异（ｘ２＝６４．８５，Ｐ＜０．０１）。早产儿动脉导管未闻发病率与胎龄无关（ｘ２＝０．３４４，Ｐ＞０．０５）。消炎痛治疗４１例，痊愈３１例（７５．８１％）。≤１５００克、２０００克、２５００克及≥２５００克等组消炎病治愈率分别１００％、９０．９１％、５３．８４％和０（ｘ２＝１３．６２，Ｐ＜０．０５），治愈率与胎龄无关。结论早产儿动脉导管未闻的发病率及消炎痛对其治愈率随出生体重增加而降低，两者与胎龄无关。

To search for the morbidity and therapeutic effect of indomethacin in the premaure infants with patent arterial duct (PAD).Methods The morbidity of PAD in premature was calculated by the cases of premature infant and PAD.The relationship between the morbidity of PAD and body weight and gestational age and the therapeutic effect of indomethacin was studied.Results The morbidity of PAD in premature infants is 5.06% (60/1185),the birth weight ≤1500g,～2000g, ～2500g and ≥2500g, the morbidities of PAD are 6.54% (10/155), 5.25% (27/514), 4.88%(19/389)and 3. 15% (4 /127) respectively,the morbidities among the groups have significant difference (X2= 64.85,P<0,01),There is not relationship between the morbidity and gestational age.The 41 cases were treated with indomethacin and 31 cases (75. 81 %) healed. The cure rates in the groups of≤1500g,～2000g,～2500g and ≥2500g are 100%, 90.91%, 53.84% and 0 respectively(X2=13.62,P<0.05).There is not relationship between cure rate and gestational age.Conclusion The morbidity and cure rate of PAD in premature infants are gradually decreased along with increase in body weight, both of them is no relationship with gestational age.