缺乏VB_6对大鼠必需脂肪酸代谢的影响

Effect of VB 6 Deficiency on Essential Fatty Acids Metabolism in Rat

以大鼠为实验动物,用高蛋白质饲料成功诱导缺乏VB6的生理状态,分析了缺乏VB6对必需脂肪酸代谢的影响。实验结果表明:缺乏维生素B6实验大鼠肝脏微粒体的△6去饱和酶活性大幅度降低、ω-6系和ω-3系必需脂肪酸代谢受到严重阻碍,肝脏和血浆脂质中出现代谢起始物的蓄积和代谢产物的显著减少,ω-3系还出现中间产物EPA的增加。

To study the VB6 action on the lipid metabolism, rats were fed with a rich in linoleic acid （ w -6） or α- linolenic acid （w -6） as lipid sources with high protein diet, the effects of VB6 deficiency on the metabolism of essential fatty acids were studied. The results showed that under VB6 deficiency conditions, the activity of △6-desaturase in liver microsome greatly decrease and the metabolism of essential fatty acid is inhibited markedly. The lack of dietary VB6 causes the accumulation of linoleic acid or α- linolenic acid, with the decrease of metabolic products observably in rat body.