桔梗醇提物对链尿菌素致糖尿病ICR小鼠血糖影响研究

Influence of Platycodon grandiflorum in Blood Glucose of Streptozotocin-induced Diabetic ICR Mice

目的:研究桔梗醇提物对链脲菌素致糖尿病ICR小鼠的血糖影响作用。方法:采用STZ尾静脉注射得到糖尿病模型小鼠,分别以含生药量8、4g/kg·bw醇提物、格林苯脲或纯净水进行28d灌胃实验,观察小鼠空腹血糖、血清胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白含量,以及体重、采食量、采水量变化。结果:长期服用PGE能缓解糖尿病ICR小鼠体重下降和多饮多食症状,高、低剂量PGE组血糖水平分别升高11.42%、6.86%,与模型对照组比较明显抑制了血糖的急剧升高;高、低剂量PVE均能显著地降低糖尿病小鼠血清TG、TC、LDL-C含量并提高HDL-C含量,同时对胰岛素的分泌也有一定的改善作用。

Objective： To study the hypoglycemic effect of Platycodon grandiflorum extract on diabetic ICR mice. Methods： Diabetic models were induced by the i.v. （intravenous） injection of streptozotocin （STZ） in ICR mice, and were divided into different groups, which were given 8, 4g/kg PGE, glibenclamide or water respectively. The effects of PGE on 28d blood glucose level of the STZ-diabetic mice were studied. Food, water intake, body weight, blood glucose, TC, TG, LDL-C, HDL-C and insulin levels were respectively tested. Result： After 28d drug administration, symptoms of diabetic mice fed PGE are alleviated obviously. Water and food intake of diabetic mice are decreased by oral administrations of PGE, and their body weight is increased. High and low doses of PVE suppress the level of blood glucose by 11.42% and 6.86% resptectively, and both doses of PGE also suppresse the levels of TC, TG and LDL-C, but increase the level of HDL-C remarkably. Insulin levels are also improved by PGE. PGE has the potential hypoglycernic effect and alleviate the diabetic symptoms on diabetic mice.