中草药补气与镇痛类药合用对小白鼠的镇痛作用研究

Effects of Chinese Herbal Medicine Mixture of Qi-tonifying Prescriptions and Analgesics on Antinociception in Mice

目的:研究中草药补气与镇痛二类药合用的镇痛作用。方法:用具有较好镇痛作用的中草药制成胶囊剂,作为对照组,再在对照组处方的基础上加入具有较好补气作用的中草药,工艺与对照组相同,制成胶囊剂,作为实验组,用二组的胶囊内容物配成所需浓度的药液给小白鼠分别灌胃,然后用热板法及甩尾法进行测定其痛阈值,实验结果与生理盐水组以及对照组与实验组作比较。结果:实验组、对照组在30min、60min、90min内与生理盐水组比较,差异均有显著性意义(P<0.05),实验组与对照组比较,差异均有显著性意义(P<0.05)。结论:在中草药镇痛类药味及剂量相同的条件下,加入具有补气作用的中草药能增强中草药制剂的镇痛疗效。

Objective： To investigate the analgesic effect administered by Chinese herbal medicine （CHM） mixture of Qi-tonifying prescriptions and analgesics. Methods： Taken the capsules made from CHM with good effect of analgesics as ＂control group＂; taken the capsules made by ＂control group＂ prescriptions mixed with some Qi-tonifymg CHM （the process is same as for ＂control group＂） as ＂experimental group （EG）＂. the mice were fed respectively by the solution prepared by the constituents of the capsules of two groups, and threshold of pain value was measured by hot plate method and whipping method. Results： EG and control group were compared with physiological saline group in 30 minutes, 60 minutes, and 90 minutes, the pain value was different significant among the three groups （P 〈 0.05）. The pain value between the EG and control group was different significantly （P 〈 0.05）. Conclusion： Under the condition of same prescriptions and equal dosages of analgesics of CHM, mixing with Qi-tonifying CHM may greatly enhance the curative effect of the analgesics.