摘要
目的:比较碳酸锂和丙戊酸钠治疗躁狂患者的疗效和副作用。方法:将52例患者随机分配到丙戊酸钠治疗组和碳酸锂治疗组。于治疗前和治疗6周后应用Bech-Rafaelsen躁狂量表(Bech-RafaelsenManiaRatingScale,BRMS)评价两药物疗效,于治疗2、4、6周应用副反应量表(TreatmentEmergentSymptomScale,TESS)评价两药物的副作用。结果:丙戊酸钠组有效率为70.8%,碳酸锂组的有效率为68.2%,两组疗效相当(P>0.05)。而碳酸锂组的副反应发生较高。结论:丙戊酸钠治疗躁狂的疗效与碳酸锂相当,而副作用较小,故此优于碳酸锂。
Objective: To investigate the therapeutic effects and side effects of Lithium and Valproate in treatment of the manic patients. Methods: Fifty-two patients with mania disorder were divided into two groups. One group was treated with Lithum, another one was treated with sodium Valproate. Bech-Rafaelsen Mania Rating Scale(BRMS) and Treatment Emergent Symptom Scale(TESS) were used to evaluate therapeutic effects and side effects. Results: There is no significant difference between the two groups in therapeutic effects (P 〉 0.05). But the side effects in the patients treated with Lithum were much higher than the patients treated with valproate(P〈0.05). Conclusion: Valproate is better than Lithum in treatment of the patients with mania disorder.
出处
《中国药物滥用防治杂志》
CAS
2006年第3期145-146,149,共3页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
碳酸锂
丙戊酸钠
躁狂
Lithium carbonate
Valproate sodium
Mania