高敏感C反应蛋白与冠心病病情及预后关系

Relationship between high sensitivity C-reaction protein and coronary heart diseases and its prognosis

目的探讨高敏感C反应蛋白(HsCRP)与冠心病(CHD)病情及预后的关系。方法选择CHD患者78例(急性心肌梗死(AMI)36例、心绞痛(AP)42例),入院时测定HsCRP,并对所有患者发病后急性期、恢复期HsCRP进行动态监测,和健康对照组结果以及传统的心脑血管疾病危险因子血清总胆固醇(TC)进行比较。结果CHD患者HsCRP水平明显高于对照组(P<0.01),AMI患者HsCRP水平及HsCRP异常检出率明显高于AP患者,且都高于TC;AMI及AP患者发病后急性期HsCRP水平显著上升,恢复期又下降至发病初水平。结论HsCRP是独立的冠心病危险因子,其对冠心病的发生及预后有较好预报作用,对评价冠心病患者的疗效有较大参考价值。

Objective It is to study the relationship between high sensitivity C-reaction protein （HsCRP） and coronary heart diseases （CHD） and its prognosis. Methods 78 cases of patients with CHD including 36 cases with acute myocardial infarction （AMI） and 42 cases with angina pectoris were chosen and their HsCRP was measured when they were hospitalized. Then the levels of HsCRP were dynamicly determined during the acute phase and convalescent phase. The results were compared with those in control group and TC. Results The levels of HsCRP in patients with CHD were significantly higher than those in the control subjects（ P〈 0.01 ）. The levels and the positive rates of HsCRP was significantly higher in patients with AMI than those in patients with AP（P〈 0.01）, and they were both higher than TC. The level of HsCRP rose in the acute phase of AMI or AP, either lowered to primal level in the convalescent phase. Conclusion HsCRP is an independent risk factor of CHD, and it has a good preventing function on the invasion and prognosis of CHD and a good referred value for evaluating the curative effect.