北京健康人群睾酮和雌二醇水平及其增龄性变化

Levels of testosterone and estradiol of the serum species from Beijing healthy people and their changes with aging

目的 调查北京地区各年龄段健康人群血清睾酮及雌二醇水平，分析其与增龄的相关性。方法用放免法测定血清样本睾酮及雌二醇浓度。结果 北京地区60～69及70-79岁二组男性健康人群血清睾酮水平显著低于青、中年人群（P〈0．05）；女性健康人群血清睾酮水平分别在30-39及60-69岁二个年龄段呈快速下降，而在30-59岁年龄区间呈相对稳定；北京地区50-59岁及60-69岁二组健康女性血清雌二醇水平显著低于20～49年龄段人群；血清睾酮及雌二醇水平与增龄间均无显著直线相关（r〉-0．975）。结论 北京地区健康人群血清睾酮及雌二醇亦平随增龄呈规律性下降，但不适宜作为人群增龄或老化的生物学指征。

Objective To investigate the serum levels of testosterone and estradiol of Beijing healthy residents at different age and to analyze their relation to aging.Methods Serum levels of testosterone and estradiol were measured by radioimmunoassay.Results The serum testosterone levels of the healthy male subjects in aged 60～69 and 70～79 groups were significantly lower than those in young and middle-age male groups(P<0.05).The serum testosterone level of the female subjects decreased rapidly in aged 30～39 and 60～69 group,while it maintained stable in aged 30～59.The serum estradiol levels of the female subjects in aged 50～59 and 60～69 groups were significantly lower than those in aged 20～49 female(P<0.05).However,there were no significantly linear relations between the serum levels of testosterone and estradiol of healthy residents and aging(r>-0.975).Conclusions The serum levels of testosterone and estradiol of Beijing healthy residents decrease regularly with aging,whereas they might not be the biomarkers of the aging for healthy people.