摘要
本文通过给予地塞米松(Dex)和糖皮质激素受体(GR)阻断剂RU38486研究GR在大鼠中性粒细胞(PMN)粘附过程中作用。结果提示:Dex可以明显抑制PMN的粘附,有浓度依赖性;在去肾上腺大鼠给予不同浓度RU38486未发现对PMN粘附有明显影响;若同时以一定的浓度比给予Dex和RU38486(Dex:RU38486)则显示Dex抑制PMN粘附程度与GR数量有依赖关系。
The model of PMN一beads adhesion and PMN一EC adhesion were usedto study the effects of GR on PMN adhesion by giving Dex and RU3 8486.Results:showdthat Dex could Obviously inhibit the PMN adhesion and with the increase of Dexconcentration the effect of inhibition could be raised It was proved that RU3 8486 had no ef-fects on the PMN adhesion through the PMN adhesion of adrenoprival rats. If Dex andRU38486 were given at a coneentration ratio of (Dex:RU38486): 1: 100 1:10 1:1 10:1 100:11000:1,the inhibition of Dex on PMN adhesion was reduced gradually till reversedcompletely.So there was a negative relation between the adhesion rate of PMN andDex一RU38486 coneentration ratio(r=0.957)The results suggested that GC inhibit PMN ad-hesion,which was mediated by GR.Since GR was blocked.the inhbition of GC would beredueed and even disappeared.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1996年第6期630-633,共4页
Chinese Journal of Pathophysiology
关键词
糖皮质激素
粒细胞
粘附
炎症
Peceptors,glucocorticoid,Granulocytes.Adhesion