NIDDM患者红细胞山梨醇与糖尿病微血管病变的关系

RELATIONSHIP BETWEEN ERYTHROCYTE SORBITOL AND DIABETIC MICROAN-GIOPATHY IN PATIENTS WITH NIDDM

测定106例NIDDM患者红细胞山梨醇(RBCS)水平,以探讨其与糖尿病微血管病变的关系。结果表明DM患者RBCS含量显著增高,其增高与尿白蛋白排泌率和糖尿病视网叹病变的严重度呈显著正相关,且同时并发上述两种病变者RBCS水平显著高于一种病变者,而仅有糖尿病视网膜病变或蛋白尿者RBCS水平又显著高于无上述两种病变者。尿白蛋白排泌率增加和糖尿病视网病变加重,RBCS水平也随之更为增高。提示DM患者RBCS水平增高在糖尿病微血管病变发生与发展中起重要作用。

To explore the relationship between the activity of polyol pathway and diabetic microangiopathy, the level of red blood cell sorbitol(RBCS)in 106 patients with NIDDMwas determined. The results indicated that the level of RBCS in diabetic patients was significantly increased, and was positively correlated with 24-h urinary albumin excretion rate(UAER)and the degree of diabetic retinopathy(DR). Besides,the value of RBCS in patients with both pro-teinuris and DR or proteinuria was markedly higher as compared with that in patients with either proteinuria or DR,and the concentration of RBCS in the patients with DR of proteinuria was also significantly higher than those wth neither proteinuria nor DR. In addition.it was also found that the value of RBCS gradually elevated with the aggravation of UAERand DR. These findings suggest that the elevation of RBCS level plays an important role in the formation and development of diabetic microangiopathy.