肺癌患者血清内皮抑素水平对肺癌早期诊断价值的研究

The value of serum endostatin level in early diagnosis of lung cancer

目的探讨肺癌患者不同临床分期、组织学类型血清内皮抑素的水平以及化疗前后其水平的变化,从而判断血清内皮抑素水平对肺癌的早期诊断和预后的价值。方法对40例肺癌患者、20例良性肺病患者和20例正常人用ELISA方法检测血清内皮抑素。对不同临床分期、病理类型及化疗前后血清内皮抑素的水平进行分析。结果(1)肺癌组血清内皮抑素水平(10．71±9．99)ng／ml高于良性肺病组(4．79±1．23)ng／ml和正常对照组(4．51±1．14)ng／ml,差异有统计学意义(P<0．01);(2)Ⅰ、Ⅱ期肺癌患者血清内皮抑素的水平高于Ⅲ期,差异有统计学意义(P<0．05)。(3)肺癌患者不同病理类型血清内皮抑素水平的比较差异无统计学意义。(4)肺癌患者化疗后血清内皮抑素水平明显高于化疗前,差异有统计学意义(P<0．05)。结论(1)血清内皮抑素可能成为肺癌早期诊断的参考指标;(2)血清内皮抑素水平的动态变化可作为化疗疗效观察和预后的评价指标。

Objective To investigate value of serum endostatin level in early diagnosis of lung cancer. Methods ELISA was used to detect the level of serum endostatin at in 40 lung carcinoma patients 18 males and 4 females, aged 59. 50 ± 14. 58. The serum endostatin levels of the lung cancer patients at different clinical stage and of different pathological types were analyzed. The change of serum endostatin level before and after chemotherapy was observed. Twenty patients with benign lung disease and 20 normal persons were used as controls. Results （ 1 ） The serum endostatin level of the lung cancer patients was 10. 71 ± 9. 99 ）ng,/ml, significantly higher than those of the patients with benign lung diseases and the normal persons （4.79 ± 1.23 ng/ml and 4.51 ± 1.14 ng/ml, respectively, beth P 〈0.01）. （2） The serum endostatin level of the lung cancer patients at the stage Ⅰ and Ⅱ were 13. 63 ± 13. 13 ng/ml and 12. 35 ± 5.79 ng/ml respectively, booth significantly higher than that of the patients at the stage m （6. 29 ± 1.64, P = 0. 023 and P = 0. 023 ）. （ 3 ） There were no significant differences in the serum endostatin level among the lung cancer patients with different pathological types. （4） The serum endostatin level of the lung cancer patients after chemotherapy was 7. 83 ± 1.48 ng/ml, significantly higher than that before the chemotherapy （5.59±1.74, P=0.04）. Conclusion （1） Rising in lung cancer at stages Ⅰ and Ⅱ, level of serum may probably be used as the a sign in early diagnosis of lung cancer. （ 2 ） After chemotherapy the level of endostatin has a trend of rising. The changes of serum endostatin level will be used as a sign in observation of treatment and prognosis.