失败种植体主要致病菌的药物敏感试验

Susceptibility of periodontopathic bacteria to antibiotics in patients with failing implants

目的:了解失败种植体主要致病菌对常用牙周病治疗药物的敏感性。方法:采用微量稀释法,测定8种抗菌药对临床分离菌株和国际模式菌株进行药物敏感性试验。结果:氧氟沙星、克林霉素、替硝唑、甲硝哒唑比其他抗生素有较强的抗菌活性。结论:失败种植体主要致病菌对常用牙周病治疗药物亦高度敏感,因此,可利用这些药物来控制种植体周围炎。

Objective：To study the antimicrobial susceptibility of periodontopathic bacteria associated with failing implants to commonly used antibiotics in periodontal therapy and dental practice, nethods：Antimicrobial susceptibility of bateria isolates was determined by the method of microbroth dilution and the activities of 8 kinds of antibiotics against international laboratory strains and clinical isolates of Provotella intermedia （Pro. I） , Porphyromonas gingivalis （Pg）, Actinobacillus actinomycetemcomitans （ Aa ） , Fusobacterium nucleatum （Fn） were examined. Results：Ofloxacin, clindamycin, tinidazole and metronidazole showed stronger antibacterial activity aginst Pro. I, Pg, Aa and Fn with MIC90≤0.5μg/ml and MBC90≤0.5μg/ml. Conclusion： Commonly-used antibiotics are potential against bacteria isolated around failing implants.