溶瘤病毒H101结合局部加热治疗对转移肿瘤病灶的远端效应

Abscopal Effect on Metastatic Tumor Induced by Oncolytic Virus of H101 Combining with Local Heating

背景与目的:远端效应是肿瘤的局部治疗引起的远处抗肿瘤作用。本研究探索溶瘤腺病毒H101局部注射结合局部加热治疗诱发远端抗瘤效应的可行性。方法:放化疗失败或拒绝放化疗并有转移病灶的5例肿瘤患者(2例鼻咽癌,1例肺癌,1例骨旁质肉瘤和1例膀胱癌),以H101(5×1011～15×1011VP)瘤内注射联合60min42℃局部热疗进行治疗。结果:2例患者注射灶、非注射灶肿瘤完全消退而长期生存,3例患者也观察到非注射病灶有不同程度缓解后死亡,生存期分别为29、15、13个月。结论:H101瘤内注射联合加热治疗能诱发一定的远端抗瘤效应。

BACKGROUND ＆ OBJECTIVE： The abscopal effect on the tumors is a distant antitumor activity induced by local treatments. The study was to observe the induction of abscopal effect by the combination of H101 oncolytic virotherapy with local heating. METHODS： Five patients with histologically confirmed, surgically unresectable metastatic malignant tumors （2 nasopharyngeal carcinomas, 1 pulmonary carcinoma, 1 parosteal sarcoma and 1 bladder carcinoma） that had definitely failed to the conventional chemotherapy and radiotherapy or refused these therapies were enrolled in this experimental therapy, All patients were treated with local intra tumor injection of H101 （5×10^11～15×10^11 VP） combined with 60-min heating at 42℃. RESULTS： Two patients were cured with complete regressions of both injected and non-injected tumors and have survived for a long period up to date. Three patients responded to the novel therapy variously and eventually died from the disease, who survived 29, 15 and 13 months, respectively. CONCLUSION： The abscopal antitumor effect could be induced by the combination of H101 local intratumoral injection with heating.