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孕妇血浆中游离胎儿DNA测定在产前诊断中的应用 被引量：2

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摘要 传统的羊膜腔穿刺和绒毛吸取是目前许多医院较为常用的产前诊断技术，因其操作易导致流产、胎儿损伤或死亡、宫内感染、羊膜破裂等，使其在临床上的推广和应用受到了限制。利用孕妇外周血中的胎儿细胞进行遗传学诊断一直是无创性产前诊断的重要探索途径。但由于孕妇外周血中的胎儿细胞数量少，而且存在个体差异，目前很难从外周血中分离出完整的胎儿细胞，这无疑限制了这种方法在临床上的应用。1997年，有学者研究发现，孕妇血液循环中存在较丰富的游离胎儿DNA，这一发现为无创性产前诊断和筛查开辟了新领域。
作者 易萍 李力 陈竹钦
机构地区 第三军医大学大坪医院野战外科研究所妇产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2006年第7期492-494,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 无创性产前诊断 游离胎儿DNA 孕妇血浆 DNA测定 孕妇外周血 羊膜腔穿刺 胎儿细胞 遗传学诊断 诊断技术 胎儿损伤
分类号 R714.5 [医药卫生—妇产科学] R992 [医药卫生—毒理学]
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参考文献26

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同被引文献18

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二级引证文献4

中华妇产科杂志
2006年 第7期

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