超声微泡造影剂携基因或药物治疗研究

Treatment of ultrasound contrast agents for gene or drug delivery

超声微泡造影剂经静脉注射到靶组织后,在超声能量作用下,因“空化效应”,能有效穿透血管内皮屏障,定向释放内部包裹的基因或药物,使局部浓度大大增高,达到靶向治疗目的。微泡可能成为靶向治疗的载体,超声造影剂作为一种新型、无创的运载系统具有广阔的应用前景。

The ultrasound microbubble agents cavitate after intravenous injection by ultrasound energy. The genes or drugs incorporated in the microbubbles can pass across the endothelial cell barrier effectively, which reach the sufficient local concentrations at the specific tissue area and achieve target treatment effect. Microbubble may be a vector for target treatment. Therefore, ultrasound contrast agent as an new and non-invasive vector for treatment holds considerable promises.