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宫颈癌相关基因HLA-DRB1编码区SNPs的生物信息学分析

Bioinformatic analysis for coding single nucleotide polymorphisms(SNPs)of HLA-DRB1 gene involved in susceptibility for cervical cancer
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摘要 目的用生物信息学的方法建立筛选宫颈癌相关基因HLA-DRB1编码区SNPs的技术平台,筛选出与宫颈癌发病相关联的SNPs。方法使用SNPper软件从公共数据库dbSNP获得HLA-DRB1编码区的SNPs数据,在dbSNP数据库获取相应的FASTA序列,使用PARSESNP软件进行分析。结果在HLA-DRB1基因的编码区发现2个SNPs(rs1059576和rs1059582),其单核苷酸的变化会引发错义突变,PSSMDifference大于10,该突变为有害突变。另外rs9269958变异则引发终止密码子的产生。结论建立的生物信息学的方法可以对基因编码区的SNPs进行分析,在众多的SNPs中搜寻出序列保守区的变异,并给出评价标准,但是所得结果需要在宫颈癌与对照人群中进行试验验证。
作者 李艳芸 邢军 徐垚 赵林胜 李燕妮 王玉川 张维铭
机构地区 天津医科大学实验中心分子生物学室
出处 《生物医学工程与临床》 CAS 2006年第4期250-253,共4页 Biomedical Engineering and Clinical Medicine
关键词 生物信息学 单核苷酸多态性(SNPs) 宫颈癌 人类白细胞抗原
分类号 R737.33 [医药卫生—肿瘤]
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参考文献11

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共引文献11

生物医学工程与临床
2006年 第4期

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