摘要
为了探讨唑来膦酸治疗骨转移引起疼痛的效果和不良反应,将恶性肿瘤骨转移引起疼痛的160例患者分为2组,治疗组78例,采用唑来膦酸4mg静脉滴入(15min以上),每4周重复1次;对照组82例采用帕米膦酸钠90mg静脉滴入6h,每4周重复1次。结果提示疼痛缓解总有效率在治疗组、对照组各为92.3%和82.9%,P=0.073。疼痛缓解后复发时间,治疗组和对照组各为16.4、12.6d,P=0.184;两组不良反应轻微,对照组发热发生率略高于治疗组。初步研究结果提示,唑来膦酸对骨转移引起的疼痛有良好的止痛效果,不良反应少。
The objective of this study was to evaluate the clinical efficacy and side effect of zoletronic acid for bone metastasis of malignance neoplasms. A total of 160 cases with bone pain of bone mallgnance metastasis were divided into two groups. In the treatment group, 78 patients received zoletronic acid (4 mg i. v. , 15 minutes, every 4 weeks). In the control group, 82 patients received pamidronate (90 mg i. v. , 6 hours, every 4 weeks). Results:Response rates of bone pain relief were 92.3% and 82.9% respectively in the zoletronic acid group and in the pamidronate group,P=0. 073. The time from relief to relapse was 16.4 days or 12.6 days in the zoletronic acid group and in the pamidronate group, respectively P=0. 184. The side effect was gentle in both groups. The Fever Percentage was found in the pamidronate group higher than in the zoletronic acid group. In conclusion, zoletronic acid can relive bone pain of metastasis effectively with little side effect.
出处
《中华肿瘤防治杂志》
CAS
2006年第12期949-950,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
唑来膦酸
帕米膦酸二钠
骨转移
骨痛
治疗
zoletronic acid
pamidronate
bone metastasis
bone pain
therapy