头颈部肿瘤放射治疗后甲状腺功能减退的研究进展

Recent reporess research on hypothyroidism induced by radiotherapy for head and neck carcinoma

近年来随着放疗技术的改进,以放疗为主的综合治疗明显提高了头颈部肿瘤患者的生存率,放疗后患者的生存质量问题,已成为目前研究的焦点之一。尽管传统观念认为甲状腺具放射抵抗性,受到照射后一般不会出现功能异常,但是近年来国内外的很多研究显示,头颈部肿瘤患者放疗后的确存在甲状腺功能低下,已对患者的生存质量构成影响。甲状腺功能减退作为头颈部肿瘤放射治疗后的并发症正逐渐受到人们的关注。放射治疗对甲状腺功能变化影响的临床研究进展,可为防治甲状腺功能减退提供依据。

Radiotherapy is one of the chief means to head and neck carcinoma. Along with improvement on radiotherapy technique, patients＇ survival rate is elevated and the quality of life has become a focus of reseach. According to traditional conception, radiation-induced hypothyroidism is rare because thyroid is a radiation-resist organ. However, nowadays hypothyroidism is a well recognized complication of radiotherapy in the treatment of head and neck cancers. To further discuss thyroid function of postradiotherapy,here we heve present the evidence in prevention and treatment of hypothyroidism.