不同负荷运动训练对大鼠血清白细胞介素2、皮质酮、下丘脑和血清β内啡肽及血浆T淋巴细胞亚群的影响

Effects of different workloads traning on IL-2, corticosterone, β-Ep and T lymphocyte subsets of rats

目的研究长时间不同负荷运动训练对大鼠免疫系统功能和神经内分泌系统反应的影响。方法将24只大鼠随机分为对照组、60min训练组、120min训练组,训练方法采用无负重游泳,其中60min游泳训练为中等强度,120min游泳训练为大强度,为期8周。结果与对照组相比,120min训练组大鼠体内T淋巴细胞亚群数目和白细胞介素2水平显著低于对照组(P<0.05),下丘脑和血清中β内啡肽,以及血清中皮质酮水平显著高于对照组;60min训练组T淋巴细胞亚群数目和白细胞介素2水平显著高于对照组,下丘脑β内啡肽显著高于对照组,而血清中β内啡肽,以及血清中皮质酮水平显著低于对照组。结论不同负荷运动训练对大鼠免疫功能和神经内分泌的影响不同,两系统之间的内部机制需进一步探讨。

Objective：To research the effect of different workloads exercise on immunity of rats＇ neuroendocrine system.Method：By experiments in different groups ,which is control group,6Omin group and 120min group ,the SD rats were conducted the swimming training for 8 weeks.Result：Compared with the control group, the IL-2 level and T lymphocyte subsets of 120min group were significantly lower than that of control; The β-Ep in the blood and the brain, also the corticosteronein the blood significantly were higher than that of the control, while the IL-2 level and T lymphocyte subsets of 60min group were significantly higher than that of control; Their corticosterone level and the β-Ep in blood was significantly lower than that of control; The β-Ep of the brain were significantly higher than that of control. Conclusion：Different changes would take place in rat immunity and neuroendocrine after long term exercise at various workloads. It is necessary to make further study on the relationship between immunity and neuroendocrine response.