脂褐素在年龄相关性黄斑变性发病中的作用

Effects of lipofuscin in morbility of age-related macular degeneration

目前年龄相关性黄斑变性是影响老年人视力和生存质量的最重要致盲眼病之一,患病率逐年提高。由于对其确切发病机制不明,故缺乏有效的防治措施。近年来研究证明,脂褐素随年龄的增长沉积于视网膜下,通过慢性光化学作用造成视网膜色素上皮细胞功能异常,光感受器细胞变性增加,脉络膜新生血管形成,导致年龄相关性黄斑变性的发生。

Age-related macular degeneration （AMD） has been one of the most important causes of irreversible blindness in old individuals nowadays. Its incidence increases year by year. Due to the uncertainty of its pathogenesis, the effective treatment for AMD is unavailable. Recently researchers have indicated lipofuscin deposites below retina along with age, and through the effect of photochemistry, the functions of retinal pigment epithelium become abnormal, Photoreceptors＇ degeneration is increased and neovascularization in choroid form resulting in the occurrence of AMD.