基质金属蛋白酶在圆锥角膜发病机制中的作用

Role of matrix metalloproteinases in the pathogenesis of keratoconus

圆锥角膜是一种先天性发育异常,是一种以角膜扩张为特征,致角膜中央部向前凸出、变薄呈圆锥并产生高度不规则散光的角膜病变。其病因不明,有研究表明基质金属蛋白酶可能参与了它的发病过程,现将这方面的研究近况作一综述。

Keratoconus is an uncommon autosomal recessive inheritance, characteristic of corneal ectasia, which results in the corneal central anterior bulging, conus formation and high irregular astigmatism. The etiopathogenisis is not clear and some research indicate that matrix metaUoproteinascs probably involved in the pathogenesis of keratoconus. Now we make a review of recent developments.