支气管肺癌血清雌三醇和催乳素的临床研究

The clinical significance for bronchial lung cancer serum estriol and prolactin

目的探测肺癌患者雌激素及催乳素水平及临床意义,试图从外周血中寻找肿瘤特异性标志物,以期对肿瘤进行早期诊断和有效的干预,并了解治疗前后血清两种激素水平是否变化。方法采用放射免疫法测定42例原发性支气管肺癌患者和34例健康体检者血清中雌三醇和催乳素水平,并检查10例肺癌患者治疗前后血清雌三醇和催乳素水平,所检测数据进行t检验。结果肺癌组雌三醇水平明显高于对照组,P<0.01;肺癌组催乳素水平明显高于对照组,P<0.01。10例接受治疗患者其治疗前后雌三醇(P>0.05)和催乳素(P>0.05)水平差异无显著性。结论肺癌患者体内存在性激素分泌代谢的失衡和紊乱,血清雌激素和催乳素水平具有辅助诊断的价值,临床检测有助于早期诊断,而治疗前后雌三醇和催乳素水平的变化能否作为预后的指标,有待进一步探讨。

Objective To discuss clinical significance of lung cancer patients＇ sexual hormone and to find tumour special symbol from plasma. Methods Detect level of estriol and prolactin in 42 primary bronchial lung cancer patients and 32 normal people with radiant immunity. With the same way 10 patients have been detected before and after their curing. Results The lung cancer group was higher in estriol and prolactin （P〈0. 01） obviously than that in comparative group. There were no changes for estriol （P〉0. 05） and prolactin＇s （P〉0. 05） level in 10 patients before and after curing. Conclusion There are sexual hormone exudation metabolize inbalance and turbalance in lung cancer patients. Clinical dictation for female and pregnant hormone can help early diagnosis.