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影响聚乳酸、聚羟基乙酸嵌段共聚物微球中蛋白、多肽类药物释放的因素 被引量：2

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摘要 目的介绍蛋白质,多肽类药物聚乳酸(PLA),聚羟基乙酸嵌段共聚物(PLGA)缓释微球近年来的研究进展,特别是影响药物释放的因素。方法根据国内外文献,从4个方面综述了影响生物大分子药物释放的因素,及如何控制突释和保持连续释放方面存在的问题及一些解决的办法。结果与结论聚合物的性质、药物的稳定性、制备工艺和附加剂的存在都会显著的影响微球的释放特性。
作者 尹东锋 钟延强
机构地区 第二军医大学药学院药剂学教研室
出处 《中国药学杂志》 CAS CSCD 北大核心 2006年第14期1049-1052,1062,共5页 Chinese Pharmaceutical Journal
关键词 蛋白质 多肽 微球 释放 聚乳酸 聚乳酸-聚羟基乙酸嵌段共聚物
分类号 R914.5 [医药卫生—药物化学]
  • 相关文献

参考文献46

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同被引文献29

  • 1金拓.进军国际技术市场是中国医药工业生存与发展的必要条件[J].中国医药工业杂志,2007,38(1). 被引量：3
  • 2宋凤兰,杨帆,张永明,李桃,杨轶群,刘星辰.基因重组人干扰素-α微球的制备及理化性质研究[J].中国药房,2007,18(10):752-754. 被引量：3
  • 3Tan ML,Choong PF,Dass CR.Recent developments in liposomes,microparticles and nanoparticles for protein and peptide drug delivery.Peptides.2010;31(1):184-193.
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  • 6Giteau A,Venier-Julienne MC,Aubert-Pou?ssel A,et al.How to achieve sustained and complete protein release from PLGA-based microparticles? Int J Pharm.2008;350(1-2):14-26.
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中国药学杂志
2006年 第14期

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