4种口服降糖药治疗2型糖尿病的成本-效果分析

Cost-effectiveness analysis of four kinds of oral hypoglycemic drugs on type 2 diabetes

目的比较4种口服降糖药治疗2型糖尿病病人的成本-效果。方法运用药物经济学成本-效果分析方法,对4种口服降糖药(A组:瑞格列奈;B组:二甲双胍;C组:格列吡嗪;D组:罗格列酮)进行评价。结果4组均可有效控制空腹血糖(P<0.05),二甲双胍、罗格列酮还可以显著降低糖化血红蛋白。结论4种治疗方案都能将血糖控制在理想范围,二甲双胍疗效较好且最经济,罗格列酮疗效最优但是价格偏高。

Aim To compare the economical effects among four kinds of oral hypoglycemic drugs on type 2 diabetes. Methods According to the principle of pharmacoeconomics,cost-effectiveness analysis （CEA） used, four kinds of oral hypoglycemic drugs （ Group A： Repaglinide ; Group B：Metformin;Group C：Glipizide;Group D：Rosiglitazone） were compared. Results Blood -fasting sugar level of patients treated with four drugs decreasde significantly （P〈0. 05） , while there were significant decrease in glyocosylated hemoglobin in Group B and Group C. Conclusion Blood-fasting sugar can be controlled by using the four drug and metformin is the cheapest drug and has better therapeutic effect, rosiglitazone, the most expensive drug,has the best therapeutic effect.