过硫酸钾存在下的盐酸胺碘酮极谱催化波及其应用

Polarographic catalytic wave of amiodarone hydrochloride in presence of persulphate and its applications

基于K2S2O8存在下盐酸胺碘酮(ADHC)产生的极谱催化波,拟定了测定ADHC的新方法。在0.15mol/LKH2PO4Na2HPO4(pH5.6)+8.0×10-5mol/LK2S2O8底液中,ADHC于-1.32V(vs.SCE)产生的极谱催化波的二阶导数峰电流ip″与其浓度在8.0×10-8～4.0×10-7mol/L及4.0×10-7～8.0×10-5mol/L呈良好的线性关系,其线性回归方程分别为ip″/μA·s-2=-3.95+9.51×107cADHC(r=0.9939,n=7),ip″/μA·s-2=104.6+2.92×107cADHC(r=0.9958,n=7),检出限为2.70×10-8mol/L。该催化波的分析灵敏度比相应还原波提高了5倍左右,该方法用于测定ADHC的含量,结果满意。

A novel method for the determination of amiodarone hydrochloride （ADHC） was proposed based on its polarographic catalytic wave in the presence of persulphate. In 0.15mol/L KH2PO4-Na2HPO4 （ pH 5.6） buffer containing 1.0 × 10^- 2 mol/L K2S2O8 supporting electrolyte, the peak potential of the polarographic catalytic wave was at - 1.32V（ vs SCE）and the 2nd-order derivative peak current of the catalytic wave was linearly proportional to the ADHC concentration in the range of 8.0 × 10^-8-4.0 × 10^-7 mol/L（r = 0.9939, n = 7） and 4.0× 10^-7 - 8.0× 10^-5mol/L（ r = 0.9958, n = 7） respectively. The detection limit was 2.70 × 10^ -8 mol/L（ 3 σ）. The sensitivity of the catalytic wave of ADHC was 5 times higher than that of the＇corresponding reduction wave. The proposed method has been applied to the direct determination of ADHC in tablets.