双环氮杂锡氧烷配合物与醛的缩合反应的研究

Studies on Aldol Condensation of Bicycloazastannoxides with Aldehyde

含席夫碱双环氮杂锡氧烷配合物的结构与ＶＢ６酶体系结构相似。以含席夫碱二苯基锡配合物（ＰｈＳｎＬ１Ｈ）为研究对象，测定了二苯基锡配合物（ＰｈＳｎＬ１Ｈ）在ＤＭＳＯ中的ｐＫａ（１７．６０），同时研究了该配合物与醛的缩合反应，合成了７种新的含β－羟基－α－氨基酸配体的有机锡配合物（ＰｈＳｎＬ１ＣＨＯＨＲⅠ～Ⅶ），并由ＩＲ、１ＨＮＭＲ、１１９ＳｎＮＭＲ及元素分析等确定了配合物的结构。

Since the structures of bicycloazastannoxide in some way conform VB6 system,the Schiff base of diphenylstannic complexes(PhSnL1H)was chosen to be the object of investigation.Its pKa in DMSO was found to be 17.6.It was subjected to react with aldehydes,and 7 novel condensation products(PhSnL1CHOHR Ⅰ-Ⅶ)β-hydroxy-α-amino acid ligands of organo-tin complexes were obtained,their IR,1H NMR,119Sn NMR and elementary analytical data were proved to have the assigned structures.