玉米须多糖治疗糖尿病作用机制的研究

Mechanism of Polysaccharide from Stigma Maydis for Diabetes Mellitus

目的为了验证玉米须多糖对糖尿病的治疗作用,并初步阐明其作用机制。方法采用四氧嘧啶法进行小鼠糖尿病造模,采用葡萄糖氧化酶法进行血糖测定,通过测定肝糖元含量的方法来观察玉米须多糖对糖代谢的影响,通过测定肝脏损伤后修复相关酶观察玉米须多糖对糖尿病小鼠糖代谢器官损伤后的修复作用。结果玉米须多糖能够降低糖尿病小鼠血糖,促进肝糖元合成,加快糖异生;对糖尿病小鼠糖代谢器官损伤有修复作用。结论玉米须多糖对糖尿病小鼠显示出良好的治疗作用,具有较好开发前景。

Objective To study the hypoglycemic effect of polysaccharide from stigma maydis and to explore its therapeutic mechanism preliminarily. Method The diabetes mice models were induced by tetraoxypyrimidine. The concentration of blood sugar was determined by glucose oxidase test. The influence of the stigma maydis polysaccharide on glycometabolism and its repair effect on damaged glycometabolism organs of diabetic mice were observed respectively by content determination of glycogen and by the measurement of activities of relative enzymes（superoxyde dismutase and glutathione peroxidase）. Results The stigma maydis polysaccharide could decrease the blood sugar, promote the synthesis of glycogen and repair the damaged glycometabolism organs of diabetic mice. Conclusion The stigma maydis polysaccharide exhibits a good therapeutic effect on diabetic mice, and has a good development prospect.