灵芝生料酿制液镇静催眠作用的研究

A Study on the Sedative and Hypnotic Effects of Ganoderma lucidum Brewage

目的考察灵芝生料酿制液(GLB)镇静催眠药理作用。方法取NIH小鼠连续灌胃0.06,0.12,0.24g/kgGLB15d,测定GLB对实验小鼠自发活动情况,对戊巴比妥钠阈下剂量、阈剂量小鼠睡眠时间和对戊四氮致小鼠惊厥的作用。结果GLB灌胃可减少小鼠自发活动,显著延长阈上剂量戊巴比妥钠致小鼠睡眠时间,增加阈下剂量戊巴比妥钠睡眠动物数,GLB与戊巴比妥钠有协同作用。有对抗戊四氮致惊厥发作的作用,且剂量越大,作用越明显。结论GLB有明显的镇静、催眠、抗惊厥等中枢抑制作用。

Objective To investigate the sedative and hypnotic effects of Ganoderma lucidum brewage （GLB）. Methods The NIH mice were given with gavage of GLB 0.06, 0. 12, and 0. 24g/kg per day respectively for 15 days. The spontaneous motion, the sleeping time induced by pentobarbital sodium in subthreshold dosage and threshold dosage, and the number of mice subjected to pentylenetetrazol - induced convulsion were observed. Results GLB can reduce the spontaneous motion, significantly longthen the mice sleeping time of pentobarbital sodium in threshold dosage and increase the number of sleeping mice under subthreshold dosage of pentobarbital sodium. GLB was synergic with pentobarbital sodium, and antagonized pentylenetetrazol - induced convulsion in a dose - dependent manner. Conclusion GLB possesses obvious sedative, hypnotic and anticonvulsive effects.