Turcot综合征的内镜特点

Endoscopic characteristics of Turcot syndrome

目的探讨Turcot综合征的内镜特点及遗传特性。方法回顾1976￣2004年所有结肠镜检查的患者,符合Turcot综合征定义的共有2例,结合文献,探讨该综合征的特点。结果家族性腺瘤样息肉病型1例为男性,55岁,遗传性非腺瘤病结直肠癌型(1ynch综合征)l例,为女性,58岁。两者均以结肠病变为首发症状,都死于脑部胶质细胞瘤。结论Turcot综合征为少见遗传病,对其加强监测,可早期诊断及时治疗,改善愈后。

[Objective] To discuss the endoscopic characteristics and hereditary of Turcot syndrome. [Method] We reviewed the patients who have been done colonoscopy from 1976 to 2004. Two cases of Turcot syndrome were found and the characteristic of the syndrome was discussed combined with literature. [Resultl One case suffered from familiar adenomatous polyposis, who is male and 55yrs old;The other is hereditary nonpolyposis colorectal cancer（Lynch syndrome）,who is female and 58yrs old. Colonic change was showed first in both patients, and the cause to death for them is same： Glioblatoma in brain. [Conclusion] Tureot syndrome is a rare hereditary disease. If monitored carefully, it can be dignosed and treated in time.