奥美拉唑联合西沙必利治疗反流性食管炎疗效观察

Effect of Omeprazole Combined with Cisapride on Reflux Esophagitis

目的:观察奥美拉唑联合西沙必利治疗反流性食管炎的疗效。方法:将68例患者随机分为观察组(36例)和对照组(32例),观察组:奥美拉唑20mg,每日2次,西沙必利5mg,每日3次;对照组:雷尼替丁150mg,每日2次,西沙必利5mg,每日3次。分别于治疗后2、4、8周观察烧心、反酸、胸痛等症状疗效,并于8周后复查胃镜,观察镜下愈合率。结果:观察组临床有效率94.44%,内镜下有效率90.91%;对照组临床有效率65.63%,内镜下有效率62.50%,两组比较差异有显著性。结论:奥美拉唑联合西沙必利治疗反流性食管炎比雷尼替丁联合西沙必利具有更好的疗效。

Objective ：To study the efficacy of omeprazole and cisapride in treating reflux esophagitis. Method ：68 cases of digestive out -patient were diagnosed with reflux esophagitis （ all by biopsy diagnosis）. They were divided into two groups,36 cases in group A （ observe group ） ：20mg of omeprazole bid, 5mg of cisapride tid were taken orally; 32 cases in group B （ control group） ： 150mg of ranitidine bid, 5mg of cisapride rid were taken orally. During the course 2,4,and 8 weeks of treatment, assess the symptom of sick, heartburn and retrostemal pain in both groups respectively, and recheck the endoscope at the end of 8 weeks. Result： The clinical curative rates were 94.4% in group A and 65.63% in group B, the efficient rates evaluation under endoscope were 90.91% ,62.50% respectively. Conclusion： The efficacy of omeprazole and cisapride in treating reflux esophagitis was obviously superior to the other group.