复发性外阴阴道念珠菌病的预防性治疗观察

Observation of Treatment of Recurrent Vulvovaginal Caudidiasis

目的:探讨复发性外阴阴道念珠菌病(RVVC)的预防性治疗效果。方法:将复发性外阴阴道念珠菌病患者59例随机分成两组,A组27例,为对照组,给伊曲康唑200mg,餐后口服,2次/d,连服2d,同时每晚阴道给药达克宁栓200mg/粒置于阴道后穹窿,连续7d。B组32例,为观察组,开始7d用药同A组,以后于每次月经干净的d1和d2餐后口服伊曲康唑200mg,每天2次,连续用药6个月。结果:A、B两组在开始治疗7d后,治愈率分别为92.59%和93.75%,差异无显著性(X2=0.0312,P>0.05);治疗3个月、6个月、12个月各阶段的复发率分别为A组20%、36%、48%,B组0、3.33%、6.67%,两组有显著性差异(X2值分别为6.599、9.785、12.275,P值分别为<0.05、<0.01、<0.001)。结论:伊曲康唑预防性治疗能有效地阻止RVVC的复发。

Objective： To explore the effect of prophylactic treatment on recurrent vulvovaginal caudidiasis （ RWC ）. Method： 59 patients with RVVC were divided randomly into two groups. 27 cases of group A （ contrast group ） were given Iraconazole （ tablet ） 200 mg p. c bid for 2 days, meanwhile Miconanole （ suppository） 1 sup （ 200 mg） bury into the hack fomix of vagina every night for 7 days. 32 cases of group B （ treatment group ） were the same medication as group A at the first 7 days, then Iraconazole 200 mg p. c bid at the first 2 days after menses for6 months. Result： Cure rate of the first 7 days treatment ：group A was 92.59%, group B was 93.75%, the difference isnt notable （ X^2 = 0. 0312, P 〉 0.05 ） ; Relapse rates of the 3,6,12 month were group A 20% ,36% ,48% and group B 0.00% ,3.33% ,6.67% ,the difference is notable （ X^2 = 6.599,9. 785,12.275, P 〈 0.05, 〈 0.01, 〈 0.001 ）. Conclusion： Prophylactic treatment by Iraconazole can prevent the relapse of RWC efficiently.