内蒙古不同浓度砷暴露人群尿砷代谢产物研究

Study on urinary arsenic metabolites of population with different concentrations of arsenic in drinking water in Inner Mongolia

目的测定内蒙古地区饮用高砷水人群尿砷代谢产物,探讨不同人群砷代谢的特点。方法采用氢化物发生原子吸收分光光度法检测尿中不同形态的砷代谢产物。结果2个暴露组人群尿中无机砷(iAs,inorganic ar-serlic)、甲基砷(MMA,monomethylarsine)、二甲基砷(DMA.dimethylarsine)和总砷(TAs,total arserlic)均高于对照组(P<0.05);同样砷暴露水平下,尿中各形态砷含量及其相对比在不同性别间的差异均无统计学意义(P>0.05),儿童DMA/MMA和DMA%高于成人(P<0.05),MMA%低于成人(P<0.05);2个暴露组儿童、成人分别与对照组比较,暴露组MMA/iAs、DMA/MMA、DMA/iAs、DMA%显著降低(P<0.05),而iAs%、MMA%显著增高(P<0.05);高暴露组与低暴露组相比,儿童DMA/MMA、DMA/iAs、DMA%显著增高(P<0.05),iAs%、MMA%显著降低(P<0.05)。结论相同砷暴露水平下,男女对砷的甲基化能力无差别,儿童二甲基化能力高于成人。高砷暴露可能降低人群对砷的生物甲基化能力。

Objective To test arsenic species in urine of people drinking high arsenic water in Inner Mongolia, and to investigate the characteristics of arsenic metabolism of different populations. Methods Arsenic species in urine were detected with hydride generation atomic absorption spectroscopy. Results Urinary concentrations of arsenic species and TAs were much higher in the two exposed groups;No sex differences in urinary among concentrations or relative ratios of arsenic species were found, while children had significant increase of DMAJMMA and DMA%, but decrease of MMA% compared with adults, exposed to the same level of arsenic. Significant increases in the values of iAs% and MMA%, accompanied by decreases of MMA/iAs, DMA/MMA, DMA/iAs and DMA% were observed in the two exposed groups; Children in higher exposed group had higher DMA/MMA, DMA/iAs, DMA% and lower iAs%, MMA% values than lower exposed group. Conclusion Male and female differences were not discernible in both high - or low - exposure group. The 2nd reaction of the metabolic pathway was more active inadults than that of children.