汕头市儿童百日咳抗体水平调查分析

Investigation on the level of antibodies against pertussis in children in Shantou City

目的了解汕头市儿童百日咳免疫水平，为预防和控制百日咳提供依据。方法选取2～15岁儿童，分为3个年龄组，用微量凝集试验检测百日咳抗体。结果分析用x^2检验、t检验、F检验。结果儿童健康人群百日咳抗体样阳性率为88．5％，保护率为33．9％，GMT为161．38％．各年龄组抗体阳性率和保护率差异有统计学意义，以6～8岁组保护率为最低。两个区的抗体阳性率和保护率差异无统计学意义。结论汕头市儿童百日咳抗体水平较低，在做好基础免疫的同时．应加强对6～8岁年龄组儿童的加强免疫。

Objective To investigate the level of antibodies against pertussis in children in Shantou City,for providing the foundation of pertussis control and prevention. Methods Children at 2-15 years of age were selected and divided into 3 age groups. The antibodies against pertussis were examined by micro-agglutination test . The results were analyzed with statistical methods ,including x^2 test, t test and F test . Results The antibodies against pertussis in children in Shantou City was 88.5 % ,in which GMT was 161. 38% ,the antibody protection rate was 33.5%. A significant difference was seen in antibody positive rate and antibody protection rate between different age groups. The antibody protection rate of 6- 8 years group was lowest. There was no significant difference in antibody positive rate and antibody protection rate between different districts. Conclusion The level of the antibodies against pertussis in children in Shantou City is not high enough to prevent pertussis epidemic. It is recommended that reinforced immunizations of pertussis for 6-8 years group should be taken seriously in addition to good basis immunizations.