摘要
Background: Ultralow- fat diets are known to reduce high- density lipoprotein cholesterol(HDL- C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL- C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods: We performed a 3- month, prospective, nonrandomized lifestyle intervention study(≤ 10% dietary fat; aerobic exercise [180 min/wk], group support, and yoga [60 min/day]) in 120 subjects with or at risk for coronary artery disease. Results: After 3 months, dietary fat intake was reduced to 8.7% ± 2.6% of total intake and the median weekly exercise time was 194 minutes. High- density lipoprotein cholesterol levels decreased by 8.3± 11.3 mg/dL(P< .001), and triglyceride levels increased by 17.6± 102.7 mg/dL(P=.026). A small dense low- density lipoprotein cholesterol(LDL- C) phenotype emerged indicated by a 13.8% LDL- C reduction accompanied by only a 2.3% reduction in apolipoprotein B levels(P=.064). Among subjects with exercise amounts less than those of the group median,HDL- C reductions were greater in those with more than(- 13.5± 16.0 mg/dL) versus less than(- 2.5± 7.5 mg/dL) the median reductions in fat intake(P=.026). Even among subjects who exercised >194 min/wk, HDL- C was reduced compared with baseline(- 7.4± 7.9 mg/dL, P< .001). Conclusions: An ultralow- fat diet as a component of a comprehensive lifestyle intervention induces reductions in HDL- C and the emergence of a dyslipidemic lipid profile. Aerobic exercise only partially mitigates this effect.
Background： Ultralow-fat diets are known to reduce high-density lipoprotein cholesterol （HDL-C） levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL-C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods： We performed a 3-month, prospective, nonrandomized lifestyle intervention study（ ≤ 10% dietary fat; aerobic exercise [ 180 min/wk], group support, and yoga [60 min/day]） in 120 subjects with or at risk for coronary artery disease. Results： After 3 months, dietary fat intake was reduced to 8.7% ± 2.6% of total intake and the median weekly exercise time was 194 minutes. High-density lipoprotein cholesterol levels decreased by 8.3 ± 11.3 mg/dL （P 〈. 001）, and triglyceride levels increased by 17.6 ± 102. 7 mg/dL（P=. 026） A small dense low-density lipoprotein cholesterol（LDL-C） phenotype emerged indicated by a 13.8% LDL-C reduction accompanied by only a 2. 3% reduction in apolipoprotein B levels（P =. 064） . Among subjects with exercise amounts less than those of the group median, HDL-C reductions were greater in those with more than（- 13.5 ± 16. 0 mg/dL） versus less than （ - 2. 5 ± 7.5 mg/dL） the median reductions in fat intake （P =. 026） . Even among subjects who exercised 〉 194 min/wk, HDL- C was reduced compared with baseline （ - 7.4 ± 7.9 mg/dL. P 〈. 001） .
