3－硝基邻苯二甲酸根桥联双核钴（Ⅱ）配合物的合成、磁性及抗癌活性

SYNTHESES,MAGNETISM AND INHIBITING CANCER ACTIVITY OF μ 3 NITROPHTHALATO BINUCLEAR COBALT(Ⅱ) COMPLEXES

合成了两种以３－硝基邻苯二甲酸根为桥联配体的新型双核钴（Ⅱ）的配合物，即［Ｃｏ２（３ＰＴ）（Ｐｈｅｎ）４］·（ＣｌＯ４）２·４Ｈ２Ｏ（配合物１）和［Ｃｏ２（３ＰＴ）（ＮＰｈｅｎ）４］（ＣｌＯ４）２·５Ｈ２Ｏ（配合物２）（３ＰＴ＝３－硝基邻苯二甲酸根，Ｐｈｅｎ＝１，１０－菲口罗啉，ＮＰｈｅｎ＝５－硝基－１，１０－菲口罗啉）。使用元素分析，ＩＲ，ＵＶ－ｖｉｓ和电导测定方法对该两配合物进行了表征。测定了配合物的变温磁化率，并对所得数据进行了理论分析，求得了配合物１、２的磁交换积分均为２Ｊ＝－９．２ｃｍ－１。对配合物进行了体外抗人白血病癌细胞实验。发现该两配合物均具有较强的抑制人白血病癌细胞的活性。

Two novel cobalt(Ⅱ) binuclear complexes,namely,[Co 2(3PT)(Phen) 4](ClO 4) 2·4H 2O (complex 1) and [Co 2(3PT)(NPhen) 4](ClO 4) 2·5H 2O (complex 2) (3PT=3 nitrophthalato,Phen=1,10 phenanthroline,NPhen=5 nitro 1,10 phenanthroline)have been synthesized.Their structures had been elucidated with elemental analysis,IR,UV Vis spectra and electronic conductance.The variable temperature susceptibility equation based on Heisenberg spin exchange operator,and the exchange intrigrals for complex 1 and 2 and 2J=9.2cm -1 .The experiments of inhibiting human leukemia cell in vitro were made,whereby the complexes exhibited the remarked function of inhibiting leukemia cell.