长托宁与阿托品在小儿术前用药的比较

Comparison of Penehyclidine Hydrochloride and Atropine Used in Pediatric Patients as Premedication

目的观察长托宁与阿托品作为术前用药对小儿的心血管、呼吸、体温、腺体分泌等方面的影响。方法3～8岁清醒合作患儿30例,随机分为长托宁组(P组)和阿托品组(A组),各15例,术前用药肌注剂量均为0.02mg/kg,记录给予观察药物前基础值(t1)、给药后10min(t2)、20min(t3)、30min(t4)、苏醒后(t5)各时点体温、呼吸频率、唾液分泌量、心率、平均动脉压(MAP)等指标。结果与基础值(t1)比较,P组:唾液分泌量减少,t2、t3、t4、t5有显著性意义(P<0.05)。A组:唾液分泌量减少及心率增快,t3、t4有显著性意义(P<0.05);面红程度大及MAP增加,t4有显著性意义(P<0.05)。组间比较:与A组比较,P组唾液分泌量减少,t4、t5有显著性意义(P<0.05);与P组比较,A组心率增快,t4有显著性意义(P<0.05)。结论与阿托品比较,在小儿术前用药中长托宁可能具有优势。

Objective To observe the influences of penehyclidine hydrochloride and atropine on cardiovascular system, breath, body temperature and saliva secretions used in pediatric patients as premedication. Methods 30 patients aged 3-8 years were randomly divided into two groups, penehyclidine hydrochloride group （group P, n=15） and atropine group （group A, n=15）, was injected with 0. 02mg/kg observed premedication, respectively. Body temperature, breath rate, amount of saliva secretions, heart rate and MAP were recorded before injection premedication（tl）, and at 10min（t2）. 20min（t3）. 30min（t4） after injection and recover consciousness（t5）. Results Compared with the baseline （tl）, in group P： secretions decreased significantly at t2.t3, t4. t5 （P〈0. 05）, in group A： secretions decreased and heart rate increased significantly at t3. t4 （P〈0. 05）, MAP increased significantly at t4 （P〈0. 05）. Compared two groups each other： in group P secretions decreased significantly compared with group A at t4. t5 （P〈0. 05）, in group A heart rate increased significantly compared with group P at t4 （P〈0. 05）. Conclusions Penehyclidine hydrochloride is possible better than atropine in pediatric patients as premedication.