不同靶浓度异丙酚对脑电频谱指数、95%边缘频率的影响

The effects of different target concentrations of propofol on BIS and 95%SEF

目的观察不同靶浓度异常丙酚对BIS、95%SEF及血流动力学的影响,评价它们之间的相关性。方法选择ASAⅠ～Ⅱ级择期手术病人10例,采用以血浆室药物浓度为靶目标进行靶控输注异丙酚,设定异丙酚的血浆浓度以1μg/ml开始,以0.5μg/ml递增,直至改良镇静警醒(OAA/S)评分=0。记录异丙酚血浆靶浓度(Ct)、效应室浓度(Ce)、BP、HR、BIS、95%SEF。结果BIS与Ct、Ce呈显著负相关,OAA/S与BIS呈正相关;结论不同靶浓度异丙酚对BIS、95%边缘频率的影响呈剂量相关性,靶渡度越高,BIS、SEF越低,BIS监测可较好地反映异丙酚麻醉的深度。

Objective To investgate the effects of different target concentrations of propofol on BIS, 95%SEF, hemodynamics and to evaluate the correlation among them.Methods Six-teen patients with ASA grade Ⅰ～Ⅱ and scheduled for elective surgery were subjected to target-controlled infusion of propofol which is based on the plasma compartment concentration, Target blood concentration of propofol was started from 1 μg/ml and then gradually increased with the concentration of every 0. 5μg/ml until the Observer＇s assessment of alertness/sedation scale （OAA/S） achieved O. Target blood concentration of propofol （Ct）, Effect compartment concentration （Ce）, BP, HR, BIS and 95%SEF were monitored and recorded. Results BIS, Ct and Ce showed significantly negative correlation, while OAA/S and BIS showed significantly positive correlation. Conclusion Different Ct of propofol exhibited the effects of dose correlation with BIS and 95%SEF. The higher the Ct, the lower the BIS and SEF, BIS is better for monitoring the level of anesthesia of propofol.