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反式翻译模型 被引量：1

A Model for Trans-translation
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摘要 反式翻译是细菌体内一种修复翻译水平上受阻的遗传信息表达过程的机制。tmRNA是反式翻译的核心分子,它兼具tRNA和mRNA的特点,在SmpB蛋白的帮助下特异性识别携带mRNA缺失体的核糖体,在核糖体蛋白S1的传递作用下结合在A位点上,一方面延续被中断的mRNA上的遗传信息,一方面终止蛋白质的合成,释放被束缚的核糖体和tRNA进入新的翻译过程。文章对近年来关于反式翻译模型的研究进行综述。 Trans-translation is a mechanism that fixes stalled translation course, tmRNA is the core of trans-translation and it has dual function as a tRNA and a mRNA. tmRNA recognizes the ribosome carrying truncated mRNA with specificity under the help SmpB protein. It can be directed to A site by ribosomal protein S1. At first tmRNA prolongs the genetic message on the stalled mRNA, then termination codon stops peptide synthesis to form a nascent chain with the tag sequence. Finally, tmRNA-SmpB system frees stalled ribosomes and directs degradation of the products of these frus trated protein synthesis reactions. This paper introduces the most recent studies on trans-translation.
作者 周海燕 吴永尧 陈建红 曾分有 田云
机构地区 湖南农业大学生化与发酵工程实验室
出处 《遗传》 CAS CSCD 北大核心 2006年第8期1051-1054,共4页 Hereditas（Beijing)
关键词 反式翻译 TMRNA SmpB蛋白 核糖体蛋白S1 trans-translation tmRNA small protein B ribosomal protein S1
分类号 Q933 [生物学—微生物学]
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参考文献15

  • 1Singh N S, Varshney U. A physiological connection between tmRNA and peptidyl-tRNA hydrolase functions in Escherichia coll.Nucleic Acids Res, 2004, 32(20): 6028-6037.
  • 2田云,卢向阳,易克,唐勇军,陈惠明.tmRNA的结构与功能[J].遗传,2004,26(3):409-413. 被引量：1
  • 3Sharkady S M, Williams K P. A third lineage with two-piece tmRNA. Nucleic Acids Res, 2004, 32(15) : 1-8.
  • 4Ivanov P V, Zvereva M I, Shpanchenko O V, Dontsova O A,Bogdanov A A, Aglyamova G V, Lim V I, Teraoka Y, Nierhaus K H. How does tmRNA move through the ribosome. FEBS Lett,2002, 514(1): 55-59.
  • 5Wower I K, Zwieb C, Wower J. Contributions of pseudoknots and protein SmpB to the structure and function of tmRNA in trens-translation. J Biol Chem, 2004, 279(52): 54202-54209.
  • 6Gutmann S, Haebel P W, Metzinger L, Sutter M, Felden B, Ban N. Crystal structure of the transfer-RNA domain of transfer-messenger RNA in complex with SmpB. Nature, 2003, 424(6949):699 -703.
  • 7Someya T, Nameki N, Hosoi H, Suzuki S, Hatanaka H, Fujii M,Terada T, Shirouzu M, Inoue Y, Shibata T, Kuramitsu S,Yokoyama S, Kawai G. Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus. FEBS Lett, 2003,535(1-3): 94-100.
  • 8Shpanchenko O V, Zvereva M I, Ivanov P V, Bugaeva E Y, Rozov A S, Bogdanov A A, Kalkum M, Isaksson L A, Nierhaus K H, Dontsova O A. Stepping tmRNA through the ribosome. J Biol Chem, 2005, 280(18) : 18368-18374.
  • 9Sundermeier T R, Dulebohn D P, Cho H J, Karzai A W. A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation. Proc Natl Acad Sci USA, 2005, 102(7): 2316-2321.
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二级参考文献25

  • 1Valle M, Gillet R, Kaur S, Henne A, Ramakrishnan V, Frank J.Visualizing tmRNA entry into a stalled ribosome. Science, 2003,300(5616): 127-130.
  • 2Williams K P. The tmRNA website: invasion by an intron.Nucleic Acids Research, 2002, 30(1): 179-182.
  • 3Zwieb C, Gorodkin J, Knudsen B, Burks J, Wower J. tmRDB (tmRNA database). Nucleic Acids Research, 2003, 31 (1):446-447.
  • 4Abo T, Inada T, Ogawa K, Aiba H. SsrA-mediated tagging and proteolysis of LacI and its role in the regulation of lac operon. The EMBO Journal, 2000, 19(14): 3762-3769.
  • 5Ranquet C, Geiselmann J, Toussaint A. The tRNA function of SsrA contributes to controlling repression of bacteriophage Mu prophage. Proc Natl Acad Sci USA, 2001, 98(18): 10220-10225.
  • 6Roche E D, Sauer R T. Identification of endogenous SsrATagged proteins reveals tagging at positions corresponding to stop codons. The Journal of Biological Chemistry, 2001, 276(30): 28509-28515.
  • 7Keiler K C, Shapiro L. tmRNA is required for correct timing of DNA replication in Caulobacter crescentus. Journal of Bacteriology, 2003, 185(2): 573-580.
  • 8Keiler K C, Shapiro L. tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation. Journal of Bacteriology, 2003, 185 (6):1825-1830.
  • 9Zwieb C, Wower I, Wower J. Comparative sequence analysis of tmRNA. Nucleic Acids Research, 1999, 27(10): 2063-2071.
  • 10Ivanov P V, Zvereva M I, Shpanchenko O V, Dontsova O A,Bogdanov A A, Aglyamova G V, Lim V I, Teraoka Y, Nierhaus K H. How does tmRNA move through the ribosome?.FEBS Letters, 2002, 514(1): 55-59.

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2006年 第8期

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