冠心病患者血液流变性研究

Analysis of Hemorheology Property in Coronary Heart Disease Patients

目的用血液流变学探讨冠心病发病机制。方法分析了68例冠心病患者血液流变学伞血高切粘度,全血低切粘度,血浆粘度,红细胞压积,全血高切还原粘度,全血低切还原粘度,红细胞变形指数,红细胞聚集指数及体外血栓形成指标变化;与68例健康人比较。结果冠心病患者血液流变学全血高切粘度,全血低切粘度,血浆粘度,红细胞压积,全血高切还原粘度,全血低切还原粘度,红细胞变形指数,红细胞聚集指数均高于正常人。体外血栓形成指标:血栓长度、血栓湿重、血栓干重也明显大于健康人。结论血液粘度增高是冠心病的诱因,也是其结果;调整冠心病患者血液流变学指标,有益于冠心病患者治疗;健康人定期检测血液流变学指标,有利于预防冠心病的发生。

Objective To make furether research on the pathogenesis of coronary heart disease. Methods The hemorheological indexes of 120 CHD patients were analysed including the whole blood viscosity in high and low shear rate, plasma viscosity, hematocrit, the whole blood reduction viscosity in high and low shear rate, deformation index of RBC, aggragation index of RBC, and in-vitro thrombosis.There indexes were compared with those of 120 healthy volunteers. Result All the above-mentioned indexes were higher than those of the normal people.The indexes of in-vitro thrombosis, including the length the wet weight and the dry weight of thrombus were also above those of healthy people.Conclusion Blood viscosity increase is not only the causing factor of CHD, but also its result. CHD patients will benefit from redressing the abnormal hemorheological indexes during there treatment. To healthy people,taking regular examines on hemorheological indexes are good for preventing CHD.