西酞普兰联合丁螺环酮治疗老年期抑郁症

Combination treatment of citalopram with buspirone for elderly depressive patients

目的探讨丁螺环酮对西酞普兰治疗老年抑郁症的增效作用。方法67例老年抑郁症患者随机分为研究组(西酞普兰联合丁螺环酮治疗,n=31)和对照组(单一西酞普兰治疗,n=36),观察12周。采用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA-17)、临床疗效总评量表(CGI-GI)和不良反应量表(TESS)分别观察疗效和不良反应。结果在治疗第1周末,2组HAMD-17、HAMA-17评分即开始下降;研究组第4周末HAMD-17评分和第8周末的HAMA-17评分均低于对照组,第12周末CGI-GI评分优于对照组(P<0.05),2组间TESS评分比较差别无统计学意义(P>0.05)。结论西酞普兰联合丁螺环酮治疗老年抑郁症可以增加疗效,且耐受性良好。

Objective To evaluate the efficacy and side effects of citalopram combined with buspirone in the treatment for elderly depressive patients. Methods Sixty-seven elderly patients who met the criteria of CCMD-3 for depression were randomly assigned to control group treated with citalopram and study group receiving combination treatment of citalopram with buspirone. HAMD-17, HAMA-17 ,CGI-GI and TESS were used to evaluate the efficacy and side effects. Results The scores of HAMD-17 in the two groups were significantly decreased 1 week after the treatment （ P 〈 0. 05 ）. The scores of HAMD-17 4 weeks after treatment and the scores of HAMA-17 8 weeks after treatment in the study group were lower than those in the control group （ P 〈 0. 05 ）. There was no significant difference between the two groups in the scores of TESS （P 〉 0. 05）. Conclusions The effect of citalopram combined with buspirone is better than eitalopram alone, and the side effects are lighter, therefore the combination is feasible in the treatment for elderly depressive patients.