MRI技术对高原人群颅脑脱髓鞘疾病回顾性研究

THE ASSOCIATION BETWEEN DEMYELINATION AND GERIATRIC CASCULAR SYNDROMES IN TIBET

目的研究高原地区,脱髓鞘疾病与中老年人疾病等因素的关系。方法对我院所有接受过磁共振头部扫描的病人进行评估,确诊出40位脱髓鞘疾病患者,并对大脑7个部位的脱髓鞘疾病按严重性分4级打分,统计临床数据,最后运用统计学方法分析其相关性。结果在40例患者中,出现在大脑半球、放射冠、半卵圆中心和脑室前后角的脑白质损伤频率最多,分别占总量的50%、67.5%、77.5%和87.5%。脑白质损伤患者的平均年龄为47.1岁,这比世界其他地区都有明显的提前。男性患者将近是女性患者的3倍(29∶11)。年龄、慢性高原红细胞增多症、收缩压、脑梗塞与脑白质损伤正相关(P<0.05)。结论对于高海拔地区,有效控制高原心血管疾病的发生对于减少颅脑脱髓鞘疾病的发生具有重要意义。

Objective To evaluate the association between cerebral dernyelination and geriatric vascular syndromes in Tibet（ average altitude above 3500m）byMRI. Methods We evaluated and graded all the patients in the NO. 1 People＇ s Hospital of Tibet from. Jan 1. 2005 to Oct 31,2005 who get demyelination in different brain regions （n=40）. Demyelination were performed by a 0.35-T MRI scan. Clinical data of these subjects are based on their case history. ANOVA test,chi-squared test and t test were performed to find variables that influenced demyelination. Results Among the 40 subjects,demyelination on cerebral hemisphere （50%） ,corona radiate（67.5% ） ,centrum semiovale （77.5%）and periventricular（87.5% ）contributed the most. The mean aging of 40 subjects （47.1±19.4 years）is more advanced than other country and regions. Aging,high altitude Polycythemia, systolic blood pressure and cerebral infarction were significantly related to the presence and severity of demyelination. Conclusions Regular and tight control for vascular disease such as high tion should be exercised to prevent demyelination in Tibet. altitude polycythemia,hypertension and cerebral infarcfion should be exercised to prevent demyelination in Tibet.